Tragoedie is one of the early drawings of Sis and Shimeji, a parody of the Gustav Klimt's painting Tragedy.
The picture consists of the front and the back part. On the front, Sis is standing with a very tough face and is holding her young sister Shimeji's face. The latter is wearing a sailor fuku, but not the one from the manga u/bouncepaw elaborate! All the traits (shimeji on the head, a fish hairpin) match. There are also 6 fishes behind and one in the front.
On the back, Chito and Yuuri are looking at a, seemingly falling, fish, together with Nuko from the outside. There's also a little bit of Kettengrad shown.